by image Ana Loose Crispy /stocksy
20 October 2025
Anxiety is on the rise, affecting approximately 60 million adults in the US and nearly a billion people worldwide. While medications and therapy remain the primary treatment, an unexpected player in mental health is emerging: gut bacteria.
A study published in EMBO Molecular Medicine Suggests that these microbes may have a direct impact on brain function—particularly anxiety levels—by regulating neuronal activity in a key fear-processing area of the brain.
Experiment: How gut bacteria affect anxiety
Researchers from Duke-NUS Medical School and the National Neuroscience Institute of Singapore conducted a preclinical study in mice to find out. gut-brain connectionThey divided the rats into two groups:
- common rats:These mice had a distinct gut microbiome.
- germ free rats: These mice, raised in completely sterile conditions, had no bacteria in their gut.
The results were surprising: The germ-free mice displayed significantly more anxious behavior than their normal counterparts.
When put to the test in the open field – a large box that had both closed and open areas – the germ-free mice preferred to hide at the edges rather than explore. In an advanced zero maze test, they spent less time in open sections, confirming that raise concern,
But the behavior was just the beginning. Researchers examined the brains of rats and found that basolateral amygdalaThe area responsible for processing fear and anxiety – was hyperactive in germ-free mice.
Their brain cells were becoming hyperactive due to impaired SK2 channels, which normally act as brakes on neuronal excitation.
key to a calm mind
to see whether gut bacteria Could restore balance, researchers suggest indoleA compound naturally produced by gut microbes in the diet of germ-free mice.
Remarkably, this simple addition Reversed brain activation and reduced their anxiety-related behaviorTreated mice became more exploratory and displayed activity patterns similar to normal mice.
This shows Gut bacteria play an essential role In controlling anxiety by producing biochemical signals that affect brain function. In other words, gut microbes may act as natural mood stabilizers.,
A potential breakthrough in mental health
This study provides strong evidence that the gut microbiome is directly linked to anxiety-related behaviors.
Although this is still early-stage research (and in this case, conducted on animals), the findings open the door to Potential new treatments for anxiety disorders in humans-Those that do not rely solely on traditional medicines, but target gut health.
Dietary Interventions for More Support
Probiotics (live beneficial bacteria):
certain probiotics—especially lactobacillus And Bifidobacteria Strain – Can help reduce stress, anxiety and depression.
Prebiotics (food for gut bacteria):
Prebiotics, such as dietary fiber and galacto-oligosaccharides (GOS), may promote the growth of beneficial bacteria.
One study found that GOS supplementation helped reduce anxiety symptoms3 Healthy women are increasing Bifidobacteria level.
Synbiotics (Probiotics + Prebiotics):
A combination of probiotics and prebiotics may provide even greater benefits.
Fermented Dairy Products:
Yogurt, kefir and other fermented dairy products naturally contain probiotics.
Spices with mental health benefits:
Some spices contain bioactive compounds that may have positive effects on the gut-brain axis.
fruits vegetables:
takeaway
Your gut microbiome isn’t just about digestion — it plays a powerful role in brain function and mental health. Research shows gut dysbiosis is linked Anxiety, Depression and Bipolar DisorderBut dietary choices can help rebalance the microbiome.
By adding probiotics, prebiotics, fermented foods, and anti-inflammatory spices to your diet, you can naturally support both gut and brain health.
Although we still have a lot to learn about the gut-brain axis, one thing is clear: do you eat It not only affects your body but it also shapes your mind.
